RESEARCH COMMUNICATION miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1
نویسندگان
چکیده
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, Singapore 117576; Stem Cell and Developmental Biology, Genome Institute of Singapore, A*STAR, Singapore 138627; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
منابع مشابه
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of the developmentally down-regulated miRNAs, ectopic overexpression of miR-191 blocks erythroid enucleation but has minor effects on proliferation and differentiation. We identified two erythroid-enriched and development...
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